Background. Serum ghrelin levels may be related to metabolic and clinical changes in patients with psoriasis. Objective.This study\nwas performed to determine the possible effects of serumghrelin in patients with psoriasis. Methods.The study population consisted\nof 25 patients with plaque psoriasis.The patients were questionedwith regard to age, gender, age of onset, duration of disease, height,\nweight, and body mass index (BMI). In addition, fasting blood sugar, triglyceride, cholesterol levels, insulin, and ghrelin levels were\nmeasured. Results.The mean serum ghrelin level was 45.41 �± 22.41 in the psoriasis group and 29.92 �± 14.65 in the healthy control\ngroup. Serumghrelin level was significantly higher in the psoriasis group compared with the controls (P = 0.01). The mean ghrelin\nlevel in patients with a lower PASI score was significantly higher than in those with a higher PASI score (P = 0.02). Conclusion.\nThe present study was performed to determine the effects of ghrelin in psoriasis patients.We found a negative correlation between\nseverity of psoriasis and ghrelin level. Larger and especially experimental studies focusing on correlation of immune system-ghrelin\nlevels and severity of psoriasis may be valuable to clarify the etiopathogenesis of the disease.
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